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<B>Comparison of Agitation and Aggression Across Dementias: Relationship to
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   Lead Investigator:    Paula Trzepacz
   Institution      :    Eli Lilly and Company
   E-Mail           :    PTT@lilly.com
   Proposal ID      :    131
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   Publications:
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1  Trzepacz PT, Saykin A, Yu P, Bhamditipati P, Sun J, Dennehy EB, Willis B, Cummings JL
   Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer's disease neuroimaging initiative and national Alzheimer's coordinating center cohorts
   Journal Article  Am J Geriatr Psychiatry,21:607-622,2013,PMC3913908
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>Agitation and aggression is a common behavioral problem in Alzheimer???s disease and other dementias. Comparisons between dementia types to evaluate the presence and types of behavioral symptoms are sparse in the literature. Prefrontal functions and frontolimbic structures have been implicated as being associated with agitation and aggression in some dementias.  Specific Aims: Analyze data from the NPI-Q items related to agitation and aggression symptom severity to compare across dementia groups.  Explore the relationship of prefrontal function as measured by selected cognitive tests with agitation and aggression symptoms.  Determine whether greater frontal cognitive dysfunction relates to behaviors as predicted by neuropathology affecting frontotemporal regions depending on the types of dementia.  Medical problems that are risk factors for dementias will be analyzed for their relationship to outcome variables as well as psychiatric history. </textarea>